Anti-Parvalbumin Antibody (L114/81)

Name: Anti-Parvalbumin Antibody
Brand: NeuroMab
SKU: 75-479
Price: 319.0 USD
Availability: InStock

Our Anti-Parvalbumin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L114/81. It detects mouse and rat Parvalbumin, and is purified by Protein A chromatography. It is great for use in AT, IHC, ICC, WB.

Adult rat somatosensory cortex immunohistochemistry.

Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with L114/81 (left) or N52A/42 (right) TC supe.

Array tomography immunofluorescence volume reconstruction of 8 serial LRWhite-embedded 70 nm sections from adult mouse cerebellum with L114/81 (green), rabbit Parvalbumin (Swant PV28, red) and DAPI (blue), with composite overlay (bottom). Images courtesy of Kristina Micheva (Stanford).

Adult rat thalamus immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Adult rat somatosensory cortex immunohistochemistry.

Species Reactivity

Mouse, Rat

Applications

AT, IHC, WB

Host Species

Mouse

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Data Sheet

SKU: 75-479

Product Details

Target

Parvalbumin alpha

Target Description

Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer (Permyakov EA et al., 2017). Parvalbumin (PV)-expressing interneurons are a class of inhibitory neurons that fire rapid barrages of action potentials, and are accordingly named “fast-spiking” interneurons (Trachtenberg J. 2015).

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L114/81

Isotype

IgG1

Applications

AT, IHC, WB

Host Species

Mouse

Gene Name

Pvalb Pva

Molecular Weight

20 kDa

Antigen

Fusion protein amino acids 1-110 (full-length) of rat Parvalbumin (also known as Parvalbumin alpha, Pvalb and Pva, accession number P02625); Mouse: 95% identity (104/110 amino acids identical); Human: 92% identity (101/110 amino acids identical); ~50% identity with Oncomodulin

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2728742

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.125

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Parvalbumin alpha

UniProt Details

UniProt (Human): Q9H598
UniProt (Immunogen Species): O35633

Product Specific References for Applications and Species

Immunohistochemistry: Mouse

Immunohistochemistry: Mouse
PMID	Dilution	Publication
37833406	not listed	Ma, D, et al. 2023. A cytoskeleton-membrane interaction conserved in fast-spiking neurons controls movement, emotion, and memory. Molecular psychiatry, .

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Anti-Parvalbumin Antibody (L114/81)

SKU: 75-479

Product Details

Product Specific References for Applications and Species

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