Anti-NSD1 Antibody (N312/10)

Name: Anti-NSD1 Antibody
Brand: NeuroMab
SKU: 75-280
Price: 361.0 USD
Availability: InStock

from NeuroMab Datasheet

Trial Size

2 Citations

Product Type

Primary Antibody

Species Reactivity

Human

Clone

N312/10

Applications

ICC, WB

Host Species

Mouse

Format

Purified

Gene Name

NSD1 ARA267 KMT3B

Molecular Weight

300 kDa

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Transfected cell immunoblot: extracts of COS cells transiently transfected with HA-tagged NSD1, NSD2, NSD3 or untagged Kv2.1 plasmids and probed with N312/10 (left), 12CA5 (middle) and K89/34 (right).

Volume: 100 µL

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Price:

$361

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Product Details

Target

Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (H4-K20-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)

Target Description

Nuclear Receptor Binding SET Domain Protein 1 is encoded by the gene NSD1. NSD1 is a member of the class V-like SAM-binding methyltransferase superfamily. NSD1 is a histone methyltransferase that is capable of both negatively or positively influencing transcription, depending on the cellular context. NSD1 is expressed in the brain, kidney, spleen, skeletal muscle, thymus, and lung. Diseases associated with NSD1 include Sotos Syndrome 1 and Overgrowth Syndrome.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N312/10

Isotype

IgG2b

Applications

ICC, WB

Host Species

Mouse

Gene Name

NSD1 ARA267 KMT3B

Molecular Weight

300 kDa

Antigen

Fusion protein amino acids 2129-2696 (C-terminus) of human NSD1 (also known as Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, H3-K36-HMTase, H4-K20- HMTase, Nuclear receptor-binding SET domain-containing protein 1, NR-binding SET domain-containing protein, Androgen receptor-associated protein of 267 kDa, Androgen receptor coactivator 267 kDa protein, Lysine N-methyltransferase 3B, ARA267 and KMT3B, accession number Q96L73); Rat: 79% identity (454/568 amino acids identical); Mouse: 79% identity (450/568 amino acids identical); 50% identity with NSD2 and NSD3

Species Reactivity

Human

Antibody Registry ID

AB_11001827

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with NSD2 or NSD3

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

UniProt Details

UniProt (Human): Q96L73
UniProt (Immunogen Species): Q96L73

Papillon-Cavanagh S1, Lu C2, Gayden T1, Mikael LG3, Bechet D1, Karamboulas C4, Ailles L4, Karamchandani J5, Marchione DM6,7, Garcia BA6, Weinreb I8, Goldstein D9, Lewis PW10, Dancu OM1, Dhaliwal S11,12, Stecho W13, Howlett CJ13, Mymryk JS14,15, Barrett JW11,12,15, Nichols AC11,12,15, Allis CD2, Majewski J1, Jabado N1,3. (2017), 'Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas..' Nat Genet. 10.1038/ng.3757.
Satterlee JS1, Beckel-Mitchener A, McAllister K, Procaccini DC, Rutter JL, Tyson FL, Chadwick LH. (2015), 'Community resources and technologies developed through the NIH Roadmap Epigenomics Program..' Methods Mol Biol. 10.1007/978-1-4939-1804-1_2.

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Anti-NSD1 Antibody (N312/10)

Anti-NSD1 Antibody
SKU: 75-280

Bulk Order Anti-NSD1 Antibody

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Anti-NSD1 Antibody (N312/10)

Anti-NSD1 Antibody SKU: 75-280

Bulk Order Anti-NSD1 Antibody

Product Details

Anti-NSD1 Antibody
SKU: 75-280