Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and HEK-293 cells stably expressing Nav1.3, and Nav1.7 and transiently expressing Kv2.1 probed with N68/6 (left) or K58/35 (right) TC supe.
Anti-Nav1.7 Na+ Channel Antibody
Nav1.7 Na+ channel
Nav1.7 subunit alpha, or SCN9A, is a member of the voltage gated sodium channel family. It is expressed at the terminal ends of sensory neurons in the dorsal root ganglion (DRG) and in trigeminal and sympathetic ganglion neurons. A major function of Nav1.7 is the generation and conduction of action potentials in nociceptors, or “pain receptors” and thus involved in pain sensation. Changes in Nav1.7 expression have been linked to primary erythermalgia, primary erythermalgia, and Congenital insensitivity to pain
IHC, IP, WB
Fusion protein amino acids 1751-1946 (cytoplasmic C-terminus) of human Nav1.7 (also known as sodium channel protein type 9 subunit alpha, neuroendocrine sodium channel, hNE-Na and peripheral sodium channel 1, accession number Q15858); Mouse: 96% identity (190/196 amino acids identical); Rat: 95% identity (186/196 amino acids identical); Shares 66-84% identity with other Nav channels
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.