Anti-Nav1.7 Na+ Channel Antibody (N68/6)
Primary Antibody
Human, Mouse, Rat
N68/6
IHC, IP, WB
Mouse
Purified
SCN9A NENA
230 kDa
Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and HEK-293 cells stably expressing Nav1.3, and Nav1.7 and transiently expressing Kv2.1 probed with N68/6 (left) or K58/35 (right) TC supe.
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Mouse | Rat
- Immunohistochemistry: Human | Mouse | Rat
- Immunoprecipitation: Rat
- Western Blot: Human | Mouse | Rat
- Additional Publications: Unspecified
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 34930944 | 1:250 | Alsaloum, M., et al. 2021. Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons. Scientific Reports, 24283. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 25995484 | 1:400 | Lu, V.B., et al. 2015. A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal.. Journal of Neuroscience, 8021-34. |
| 18988673 | 1:100 | Ernst, S.J., et al. 2009. Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion.. Endocrinology, 1132-9. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 31501450 | 1:500 | Vysokov, N., et al. 2019. The role of Na V channels in synaptic transmission after axotomy in a microfluidic culture platform. Scientific Reports, 12915. |
| 27940916 | not listed | Dustrude, E.T., et al. 2016. Hierarchical CRMP2 posttranslational modifications control NaV1.7 function. PNAS, E8443-52. |
| 21486703 | 1:500 | Chattopadhyay, M., et al. 2011. Vector-mediated release of GABA attenuates pain-related behaviors and reduces Na(V)1.7 in DRG neurons.. European Journal of Pain, 913-20. |
| 20635406 | 1:250 | Cox, J.J., et al. 2010. Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations.. Human Mutation, 1670-86. |
| Immunohistochemistry: Human | ||
| PMID | Dilution | Publication |
| 33550628 | 2ug/ml | Shiers, S.I., et al. 2021. Convergence of peptidergic and non-peptidergic protein markers in the human dorsal root ganglion and spinal dorsal horn. The Journal of Comparative Neurology, 2771-88. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 30125271 | not listed | Nunes, D., et al. 2018. Axonal sodium channel NaV1. 2 drives granule cell dendritic GABA release and rapid odor discrimination. . PLoS Biology, e2003816. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 36358921 | 1:200 | Reid, A., et al. 2022. Long-Term Blockade of Nociceptive Nav1.7 Channels Is Analgesic in Rat Models of Knee Arthritis. Biomolecules, 1571. |
| 31550995 | 5 µg/mL | Grubinska, B., et al. 2019. Rat Na V 1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers. Molecular Pain, 1744806919881840. |
| 23642408 | 25 µg/mL | Liang, L., et al. 2013. Protein kinase B/Akt is required for complete Freund''s adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons.. The Journal of Pain, 638-47. |
| 23022218 | 1:100 | Cachemaille, M., et al. 2012. Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain.. Neuroscience, 370-80. |
| Immunoprecipitation: Rat | ||
| PMID | Dilution | Publication |
| 29956586 | 10 ug | Dash, B., et al. 2018. Nonmuscle myosin II isoforms interact with sodium channel alpha subunits. . Molecular Pain, 1744806918788630. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 24009557 | not listed | Laedermann, C.J., et al. 2013. β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells.. Frontiers in Neuroscience, 137. |
| 23986482 | not listed | Campbell, T.M., et al. 2013. Functional expression of the voltage-gated Na⁺-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells.. Journal of Cell Science, 4939-49. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 35131865 | 1:500 | Deftu, A.F., et al. 2022. The anti-diabetic drug metformin regulates voltage-gated sodium channel NaV1.7 via the ubiquitin-ligase NEDD4-2. eNeuro, ENEURO.0409-21.2022. |
| 30125271 | not listed | Nunes, D., et al. 2018. Axonal sodium channel NaV1. 2 drives granule cell dendritic GABA release and rapid odor discrimination. . PLoS Biology, e2003816. |
| 27604420 | 1:500 | Yanpallewar, S., et al. 2016. Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli. Scientific Reports, 32957. |
| 25620605 | 1:500 | Vandael, D.H., et al. 2015. Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells.. The Journal of Physiology, 905-27. |
| 23607966 | 1:100 | Melemedjian, O.K., et al. 2013. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.. Pain, 1080-91. |
| 23095258 | not listed | Liu, J., et al. 2012. Voltage-gated sodium channel expression and action potential generation in differentiated NG108-15 cells.. BMC Neuroscience, 129. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 37669448 | 1:1000 | Cui, Y, et al. 2023. Ropivacaine promotes axon regeneration by regulating Nav1.8-mediated macrophage signaling after sciatic nerve injury in rats. Anesthesiology, 0. |
| 31550995 | 10 µg | Grubinska, B., et al. 2019. Rat Na V 1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers. Molecular Pain, 1744806919881840. |
| 27940916 | not listed | Dustrude, E.T., et al. 2016. Hierarchical CRMP2 posttranslational modifications control NaV1.7 function. PNAS, E8443-52. |
| 23642408 | 1:1000 | Liang, L., et al. 2013. Protein kinase B/Akt is required for complete Freund''s adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons.. The Journal of Pain, 638-47. |
| 23095258 | not listed | Liu, J., et al. 2012. Voltage-gated sodium channel expression and action potential generation in differentiated NG108-15 cells.. BMC Neuroscience, 129. |
| 22408255 | 10 µg | Ho, C., et al. 2012. Differential expression of sodium channel β subunits in dorsal root ganglion sensory neurons.. The Journal of Biological Chemistry, 15044-53. |
| 22273495 | not listed | Yan, J., et al. 2012. Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6).. Molecular Pain, 6. |
| Additional Publications: Unspecified | ||
| PMID | Publication | |
| 30894674 | Bugan, I., et al. 2019. Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate. Prostate Cancer and Prostatic Diseases, 569-79. | |
| 30565051 | Yu, J., et al. 2019. Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission. Molecular Neurobiology, 5241-55. | |
| 29655575 | Moutal, A., et al. 2018. CRMP2-Neurofibromin Interface Drives NF1-related Pain. Neuroscience, 79-90. | |
| 23836888 | Dustrude, E.T., et al. 2013. CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking.. The Journal of Biological Chemistry, 24316-31. | |
| 22071319 | Tappe-Theodor, A., et al. 2012. Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization.. Pain, 184-96. | |