Anti-Nav1.7 Na+ Channel Antibody (N68/6)

Name: Anti-Nav1.7 Na+ Channel Antibody
Brand: NeuroMab
SKU: 75-103
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet

filler

Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

SCN9A NENA

Molecular Weight

230 kDa

Go to Full Product Details

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and HEK-293 cells stably expressing Nav1.3, and Nav1.7 and transiently expressing Kv2.1 probed with N68/6 (left) or K58/35 (right) TC supe.

Product Details

Target

Nav1.7 Na+ channel

Target Description

Nav1.7 subunit alpha, or SCN9A, is a member of the voltage gated sodium channel family. It is expressed at the terminal ends of sensory neurons in the dorsal root ganglion (DRG) and in trigeminal and sympathetic ganglion neurons. A major function of Nav1.7 is the generation and conduction of action potentials in nociceptors, or “pain receptors” and thus involved in pain sensation. Changes in Nav1.7 expression have been linked to primary erythermalgia, primary erythermalgia, and Congenital insensitivity to pain

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N68/6

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

SCN9A NENA

Molecular Weight

230 kDa

Antigen

Fusion protein amino acids 1751-1946 (cytoplasmic C-terminus) of human Nav1.7 (also known as sodium channel protein type 9 subunit alpha, neuroendocrine sodium channel, hNE-Na and peripheral sodium channel 1, accession number Q15858); Mouse: 96% identity (190/196 amino acids identical); Rat: 95% identity (186/196 amino acids identical); Shares 66-84% identity with other Nav channels

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2184355

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against other Nav channels

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)

UniProt Details

UniProt (Human): Q15858
UniProt (Immunogen Species): Q15858

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Anti-Nav1.7 Na+ Channel Antibody (N68/6)

Anti-Nav1.7 Na+ Channel Antibody
SKU: 75-103

Product Details

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Anti-Nav1.7 Na+ Channel Antibody (N68/6)

Anti-Nav1.7 Na+ Channel Antibody SKU: 75-103

Product Details

Anti-Nav1.7 Na+ Channel Antibody
SKU: 75-103