Name: Anti-Metabotropic Glutamate Receptor 1a Antibody
Brand: PhosphoSolutions
SKU: 2031-mGluR1a
Price: 415.0 USD
Availability: InStock

Our Anti-Metabotropic Glutamate Receptor 1a primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse and rat Metabotropic Glutamate Receptor 1a and is antigen affinity purified. It is great for use in WB, IHC.

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Applications

IHC, WB

Host Species

Rabbit

Format

Antigen Affinity Purified

Gene Name

GRM1

Molecular Weight

125/250 kDa

Go to Full Product Details

Western blot of 10 µg of HEK 293 cells expressing: 1) mGluR5 and 2) mGluR1a. Specific immunolabeling of the ~125 kDa monomer and the ~250 kDa dimer of mGluR1a is shown in the second lane (2). Specificity is confirmed in the first lane (1), as the mGluR1a antibody shows no reactivity toward mGluR5.

Volume: 100 µL

Variant

Price:

$415

Quantity:

Bulk Order Anti-Metabotropic Glutamate Receptor 1a Antibody

Product Details

Target

Metabotropic Glutamate Receptor 1a

Target Description

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003).

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Rabbit

Gene Name

GRM1

Molecular Weight

125/250 kDa

Antigen

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat mGluR1a, conjugated to keyhole limpet hemocyanin (KLH).

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2492150

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum using a column to which the peptide immunogen was coupled.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
IHC: 1:500

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~125 kDa monomer and the ~250 kDa mGluR1a dimer. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Glutamate receptor metabotropic 1 antibody, GPRC1A antibody, GRM1 alpha antibody, GRM1 antibody, GRM1_HUMAN antibody, Metabotropic glutamate receptor 1 antibody, MGLU1 antibody, mGluR1 antibody, SCAR13 antibody

UniProt Details

UniProt (Immunogen Species): P23385

NCBI Gene ID

24414

Product Specific References for Applications and Species

Western Blot: Rat

Western Blot: Rat
PMID	Dilution	Publication
30946882	1:1000	Gobin, C., et al. 2019. Neurobiological substrates of persistent working memory deficits and cocaine-seeking in the prelimbic cortex of rats with a history of extended access to cocaine self-administration. Neurobiology of Learning and Memory, 161, pp.92-105.

Product Specific Protocols

Western Blot Protocol: Download

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Anti-Metabotropic Glutamate Receptor 1a Antibody

Our Anti-Metabotropic Glutamate Receptor 1a primary antibody from PhosphoSolutions is rabbit polyclonal. It detects mouse and rat Metabotropic Glutamate Receptor 1a and is antigen affinity purified. It is great for use in WB, IHC.