Primary Antibody
Human, Mouse, Rat
K89/34
IHC, IP, WB
Mouse
Purified
Kcnb1
105-125 kDa (varies with cell background due to phosphorylation)
- Bishop HI, Cobb MM, Kirmiz M, Parajuli LK, Mandikian D, Philp AM, Melnik M, Kuja-Panula J, Rauvala H, Shigemoto R, Murray KD, Trimmer JS. (2018), 'Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons..' Frontiers in Molecular Neuroscience. 10.3389/fnmol.2018.00001.
- Yu W, Parakramaweera R, Teng S, Gowda M, Sharad Y, Thakker-Varia S, Alder J, Sesti F. (2016), 'Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury..' Journal of Neuroscience. 10.1523/JNEUROSCI.2273-16.2016.
- Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K. (2016), 'Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons..' Acta Neuropathol Commun.. 10.1186/s40478-016-0286-7.
- Frazzini V, Guarnieri S, Bomba M, Navarra R, Morabito C, Mariggiò MA, Sensi SL, (2016), 'Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer''s disease mouse model..' Cell Death & Disease. 10.1038/cddis.2016.18.
- Peltola MA, Kuja-Panula J, Liuhanen J, Võikar V, Piepponen P, Hiekkalinna T, Taira T, Lauri SE, Suvisaari J, Kulesskaya N, Paunio T, Rauvala H. (2016), 'AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes..' Schizophrenia Bulletin. 10.1093/schbul/sbv105.
- Bishop HI, Guan D, Bocksteins E, Parajuli LK, Murray KD, Cobb MM, Misonou H, Zito K, Foehring RC, Trimmer JS. (2015), 'Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons..' Journal of Neuroscience. 10.1523/JNEUROSCI.1897-15.2015.
- Vullhorst D, Mitchell RM, Keating C, Roychowdhury S, Karavanova I, Tao-Cheng JH, Buonanno A. (2015), 'A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling..' Nature Communications. 10.1038/ncomms8222.
- Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell''Acqua ML, Scott JD, Navedo MF. (2015), 'Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes..' The Journal of Biological Chemistry. 10.1074/jbc.M114.622811.
- Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT. (2015), 'A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization..' The Journal of General Physiology. 10.1085/jgp.201511444.
- Wu Y, Shyng SL, Chen PC. (2015), 'Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells..' The Journal of Biological Chemistry. 10.1074/jbc.M115.670877.
- Cobb MM, Austin DC, Sack JT, Trimmer JS. (2015), 'Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells..' The Journal of Biological Chemistry. 10.1074/jbc.M115.690198.
- El Gebeily G, El Khoury N, Mathieu S, Brouillette J, Fiset C. (2015), 'Estrogen regulation of the transient outward K(+) current involves estrogen receptor α in mouse heart..' Journal of Molecular and Cellular Cardiology. 10.1016/j.yjmcc.2015.07.013.
- He K, McCord MC, Hartnett KA, Aizenman E. (2015), 'Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels..' PLoS One. 10.1371/journal.pone.0129498.
- Fox PD, Haberkorn CJ, Akin EJ, Seel PJ, Krapf D, Tamkun MM. (2015), 'Induction of stable ER-plasma-membrane junctions by Kv2.1 potassium channels..' Journal of Cell Science. 10.1242/jcs.166009.
- Liu J, Magri L, Zhang F, Marsh NO, Albrecht S, Huynh JL, Kaur J, Kuhlmann T, Zhang W, Slesinger PA, Casaccia P. (2015), 'Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation..' Journal of Neuroscience. 10.1523/JNEUROSCI.2606-14.2015.
- Ednie AR, Bennett ES. (2015), 'Reduced sialylation impacts ventricular repolarization by modulating specific K+ channel isoforms distinctly..' The Journal of Biological Chemistry. 10.1074/jbc.M114.605139.
- Jensen CS, Misonou H. (2015), 'Live-cell imaging of post-golgi transport vesicles in cultured hippocampal neurons..' Cell Molecular Neurobiology. 10.1007/s10571-014-0103-4.
- Torkamani A, Bersell K, Jorge BS, Bjork RL Jr, Friedman JR, Bloss CS, Cohen J, Gupta S, Naidu S, Vanoye CG, George AL Jr, Kearney JA. (2014), 'De novo KCNB1 mutations in epileptic encephalopathy..' Annals of Neurology. 10.1002/ana.24263.
- Mandikian D, Bocksteins E, Parajuli LK, Bishop HI, Cerda O, Shigemoto R, Trimmer JS. (2014), 'Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors..' Journal of Comparative Neurology. 10.1002/cne.23641.
- Moutal A, François-Moutal L, Brittain JM, Khanna M, Khanna R. (2014), 'Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides..' Frontiers in Neuroscience. 10.3389/fncel.2014.00471.
- Krasowska E, Zabłocki K, Górecki DC, Swinny JD. (2014), 'Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice: implications for cognitive impairment in duchenne muscular dystrophy..' PLoS One. 10.1371/journal.pone.0108364.
- Siddoway B, Hou H, Yang J, Sun L, Yang H, Wang GY, Xia H. (2014), 'Potassium channel Kv2.1 is regulated through protein phosphatase-1 in response to increases in synaptic activity..' Neuroscience Letters. 10.1016/j.neulet.2014.08.051.
- McCord MC, Kullmann PH, He K, Hartnett KA, Horn JP, Lotan I, Aizenman E. (2014), 'Syntaxin-binding domain of Kv2.1 is essential for the expression of apoptotic K+ currents..' The Journal of Physiology. 10.1113/jphysiol.2014.276964.
- Dufour MA, Woodhouse A, Goaillard JM. (2014), 'Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development..' Journal of Neuroscience Research. 10.1002/jnr.23382.
- Shah NH, Schulien AJ, Clemens K, Aizenman TD, Hageman TM, Wills ZP, Aizenman E. (2014), 'Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia..' Journal of Neuroscience. 10.1523/JNEUROSCI.5184-13.2014.
- Kirizs T, Kerti-Szigeti K, Lorincz A, Nusser Z. (2014), 'Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells..' European Journal of Neuroscience. 10.1111/ejn.12526.
- Wang CY, Huang AQ, Zhou MH, Mei YA. (2014), 'GDF15 regulates Kv2.1-mediated outward K+ current through the Akt/mTOR signalling pathway in rat cerebellar granule cells..' Biochemical Journal. 10.1042/BJ20140155.
- Jensen CS, Watanabe S, Rasmussen HB, Schmitt N, Olesen SP, Frost NA, Blanpied TA, Misonou H. (2014), 'Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons..' The Journal of Biological Chemistry. 10.1074/jbc.M113.534495.
- Speca DJ, Ogata G, Mandikian D, Bishop HI, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS. (2014), 'Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability..' Genes, Brain and Behavior. 10.1111/gbb.12120.
- King AN, Manning CF, Trimmer JS. (2014), 'A unique ion channel clustering domain on the axon initial segment of mammalian neurons..' Journal of Comparative Neurology. 10.1002/cne.23551.
- Hund TJ, Snyder JS, Wu X, Glynn P, Koval OM, Onal B, Leymaster ND, Unudurthi SD, Curran J, Camardo C, Wright PJ, Binkley PF, Anderson ME, Mohler PJ. (2014), 'β(IV)-Spectrin regulates TREK-1 membrane targeting in the heart..' Cardiovascular Research. 10.1093/cvr/cvu008.
- Maguire EP, Macpherson T, Swinny JD, Dixon CI, Herd MB, Belelli D, Stephens DN, King SL, Lambert JJ. (2014), 'Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants..' Journal of Neuroscience. 10.1523/JNEUROSCI.3232-13.2014.
- Lopez-Izquierdo A, Pereira RO, Wende AR, Punske BB, Abel ED, Tristani-Firouzi M. (2014), 'The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization..' American Journal of Physiology-Heart and Circulatory Physiology. 10.1152/ajpheart.00849.2013.
- Pirger Z, Battonyai I, Krajcs N, Elekes K, Kiss T. (2014), 'Voltage-gated membrane currents in neurons involved in odor information processing in snail procerebrum..' Brian Structure and Function. 10.1007/s00429-013-0526-6.
- Cservenák M, Szabó ÉR, Bodnár I, Lékó A, Palkovits M, Nagy GM, Usdin TB, Dobolyi A. (2013), 'Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation..' PsychoneuroEndocrinology. 10.1016/j.psyneuen.2013.09.004.
- Shepherd AJ, Loo L, Mohapatra DP. (2013), 'Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure..' PLoS One. 10.1371/journal.pone.0076698.
- McCord MC, Aizenman E. (2013), 'Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1306238110.
- Guan D, Armstrong WE, Foehring RC. (2013), 'Kv2 channels regulate firing rate in pyramidal neurons from rat sensorimotor cortex..' The Journal of Physiology. 10.1113/jphysiol.2013.257253.
- Amako Y, Igloi Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, Peers C, Harris M. (2013), 'Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis..' The Journal of Biological Chemistry. 10.1074/jbc.M113.491985.
- Mavlyutov TA, Epstein ML, Verbny YI, Huerta MS, Zaitoun I, Ziskind-Conhaim L, Ruoho AE. (2013), 'Lack of sigma-1 receptor exacerbates ALS progression in mice..' Neuroscience. 10.1016/j.neuroscience.2013.02.035.
- Kourrich S, Hayashi T, Chuang JY, Tsai SY, Su TP, Bonci A. (2013), 'Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine..' Cell. 10.1016/j.cell.2012.12.004.
- Fox PD, Loftus RJ, Tamkun MM. (2013), 'Regulation of Kv2.1 K(+) conductance by cell surface channel density..' Journal of Neuroscience. 10.1523/JNEUROSCI.3008-12.2013.
- Shepherd AJ, Loo L, Gupte RP, Mickle AD, Mohapatra DP. (2012), 'Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics..' Journal of Neuroscience. 10.1523/JNEUROSCI.3029-12.2012.
- Tsantoulas C, Zhu L, Shaifta Y, Grist J, Ward JP, Raouf R, Michael GJ, McMahon SB. (2012), 'Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury..' Journal of Neuroscience. 10.1523/JNEUROSCI.3561-12.2012.
- Smith KE, Wilkie SE, Tebbs-Warner JT, Jarvis BJ, Gallasch L, Stocker M, Hunt DM. (2012), 'Functional analysis of missense mutations in Kv8.2 causing cone dystrophy with supernormal rod electroretinogram..' The Journal of Biological Chemistry. 10.1074/jbc.M112.388033.
- Norris CA, He K, Springer MG, Hartnett KA, Horn JP, Aizenman E. (2012), 'Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A..' Journal of Neuroscience. 10.1523/JNEUROSCI.0937-12.2012.
- Manning CF, Bundros AM, Trimmer JS (2012), 'Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance..' PLoS One. 10.1371/journal.pone.0038313.
- Menegola M, Clark E, Trimmer JS. (2012), 'The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice..' Epilepsia. 10.1111/j.1528-1167.2012.03485.x.
- Al-Owais MM, Scragg JL, Dallas ML, Boycott HE, Warburton P, Chakrabarty A, Boyle JP, Peers C. (2012), 'Carbon monoxide mediates the anti-apoptotic effects of heme oxygenase-1 in medulloblastoma DAOY cells via K+ channel inhibition..' The Journal of Biological Chemistry. 10.1074/jbc.M112.357012.
- Kinoshita M, Matsuoka Y, Suzuki T, Mirrielees J, Yang J. (2012), 'Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands..' Brain Research. 10.1016/j.brainres.2012.02.070.
- Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AM, Gaisano HY, Lotan I, Macdonald PE. (2012), 'The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function..' Diabetologia. 10.1007/s00125-012-2512-6.
- Zhou MH, Yang G, Jiao S, Hu CL, Mei YA. (2012), 'Cholesterol enhances neuron susceptibility to apoptotic stimuli via cAMP/PKA/CREB-dependent up-regulation of Kv2.1..' Journal of Neurochemistry. 10.1111/j.1471-4159.2011.07593.x.
- Song MY, Hong C, Bae SH, So I, Park KS. (2012), 'Dynamic modulation of the kv2.1 channel by SRC-dependent tyrosine phosphorylation..' Journal of Proteome Research. 10.1021/pr200770v.
- Peltola MA, Kuja-Panula J, Lauri SE, Taira T, Rauvala H. (2012), 'AMIGO is an auxiliary subunit of the Kv2.1 potassium channel..' EMBO Reports. 10.1038/embor.2011.204.
- Ikematsu N, Dallas ML, Ross FA, Lewis RW, Rafferty JN, David JA, Suman R, Peers C, Hardie DG, Evans AM. (2011), 'Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1106201108.
- Joseph BK, Thakali KM, Pathan AR, Kang E, Rusch NJ, Rhee SW. (2011), 'Postsynaptic density-95 scaffolding of Shaker-type K⁺ channels in smooth muscle cells regulates the diameter of cerebral arteries..' The Journal of Physiology. 10.1113/jphysiol.2011.213843.
- Brittain JM, Chen L, Wilson SM, Brustovetsky T, Gao X, Ashpole NM, Molosh AI, You H, Hudmon A, Shekhar A, White FA, Zamponi GW, Brustovetsky N, Chen J, Khanna R. (2011), 'Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2)..' The Journal of Biological Chemistry. 10.1074/jbc.M111.255455.
- Cerda O, Trimmer JS. (2011), 'Activity-dependent phosphorylation of neuronal Kv2.1 potassium channels by CDK5..' The Journal of Biological Chemistry. 10.1074/jbc.M111.251942.
- Mihelec M, Pearson RA, Robbie SJ, Buch PK, Azam SA, Bainbridge JW, Smith AJ, Ali RR. (2011), 'Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency..' Human Gene Therapy. 10.1089/hum.2011.069.
- Guan D, Horton LR, Armstrong WE, Foehring RC. (2011), 'Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons..' Journal of Neurophysiology. 10.1152/jn.00758.2010.
- Zhuang JL, Wang CY, Zhou MH, Duan KZ, Mei YA. (2011), 'TGF-β1 enhances Kv2.1 potassium channel protein expression and promotes maturation of cerebellar granule neurons..' Journal of Cellular Physiology. 10.1002/jcp.22735.
- Dallas ML, Boyle JP, Milligan CJ, Sayer R, Kerrigan TL, McKinstry C, Lu P, Mankouri J, Harris M, Scragg JL, Pearson HA, Peers C. (2011), 'Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1..' The FASEB Journal. 10.1096/fj.10-173450.
- Schwetz TA, Norring SA, Ednie AR, Bennett ES. (2011), 'Sialic acids attached to O-glycans modulate voltage-gated potassium channel gating..' The Journal of Biological Chemistry. 10.1074/jbc.M110.171322.
- Song MY, Moon YJ, Shin SK, Kim TY, Yune TY, Park KS. (2011), 'Contribution of the delayed-rectifier potassium channel Kv2.1 to acute spinal cord injury in rats..' BMB Reports. 10.5483/BMBRep.2010.43.11.756.
- Nataraj K, Le Roux N, Nahmani M, Lefort S, Turrigiano G. (2010), 'Visual deprivation suppresses L5 pyramidal neuron excitability by preventing the induction of intrinsic plasticity..' Neuron. 10.1016/j.neuron.2010.09.033.
- Yang KC, Foeger NC, Marionneau C, Jay PY, McMullen JR, Nerbonne JM. (2010), 'Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy..' The Journal of Physiology. 10.1113/jphysiol.2010.197418.
- Hermanstyne TO, Kihira Y, Misono K, Deitchler A, Yanagawa Y, Misonou H. (2010), 'Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice..' Journal of Comparative Neurology. 10.1002/cne.22457.
- Kihira Y, Hermanstyne TO, Misonou H. (2010), 'Formation of heteromeric Kv2 channels in mammalian brain neurons..' The Journal of Biological Chemistry. 10.1074/jbc.M109.074260.
- Mavlyutov TA, Epstein ML, Andersen KA, Ziskind-Conhaim L, Ruoho AE. (2010), 'The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study..' Neuroscience. 10.1016/j.neuroscience.2010.02.022.
- Ito T, Nuriya M, Yasui M. (2010), 'Regulation of Kv2.1 phosphorylation in an animal model of anoxia..' Neurobiology of Disease. 10.1016/j.nbd.2010.01.002.
- Aras MA, Saadi RA, Aizenman E. (2009), 'Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia..' European Journal of Neuroscience. 10.1111/j.1460-9568.2009.07026.x.
- Mankouri J, Dallas ML, Hughes ME, Griffin SD, Macdonald A, Peers C, Harris M. (2009), 'Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.0906798106.
- Eyre MD, Kerti K, Nusser Z. (2009), 'Molecular diversity of deep short-axon cells of the rat main olfactory bulb..' European Journal of Neuroscience. 10.1111/j.1460-9568.2009.06703.x.
- Mulholland PJ, Carpenter-Hyland EP, Woodward JJ, Chandler LJ. (2009), 'Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus..' Alcohol. 10.1016/j.alcohol.2008.10.001.
- Mulholland PJ, Carpenter-Hyland EP, Hearing MC, Becker HC, Woodward JJ, Chandler LJ. (2008), 'Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels..' Journal of Neuroscience. 10.1523/JNEUROSCI.2405-08.2008.
- Misonou H, Thompson SM, Cai X. (2008), 'Dynamic regulation of the Kv2.1 voltage-gated potassium channel during brain ischemia through neuroglial interaction..' Journal of Neuroscience. 10.1523/JNEUROSCI.1417-08.2008.
- Micheva KD, Smith SJ. (2007), 'Array tomography: a new tool for imaging the molecular architecture and ultrastructure of neural circuits..' Neuron. 10.1016/j.neuron.2007.06.014.
- Guan D, Tkatch T, Surmeier DJ, Armstrong WE, Foehring RC. (2007), 'Kv2 subunits underlie slowly inactivating potassium current in rat neocortical pyramidal neurons..' The Journal of Physiology. 10.1113/jphysiol.2007.128454.
- Pott C, Ren X, Tran DX, Yang MJ, Henderson S, Jordan MC, Roos KP, Garfinkel A, Philipson KD, Goldhaber JI. (2007), 'Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice..' American Journal of Physiology-Cell Physiology. 10.1152/ajpcell.00177.2006.
- Misonou H, Menegola M, Mohapatra DP, Guy LK, Park KS, Trimmer JS. (2006), 'Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation..' Journal of Neuroscience. 10.1523/JNEUROSCI.3970-06.2006.
- Tozakidou M, Goltz D, Hagenström T, Budack MK, Vitzthum H, Szlachta K, Bähring R, Ehmke H. (), 'Molecular and functional remodeling of I(to) by angiotensin II in the mouse left ventricle..' Journal of Molecular and Cellular Cardiology. 10.1016/j.yjmcc.2009.08.027.