Anti-Kv2.1 K+ Channel Antibody (K89/34)

Name: Anti-Kv2.1 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-014
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated Trial Size

filler

Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Go to Full Product Details

Adult rat hippocampus immunohistochemistry.

Immunoblot on adult mouse brain membranes from two wild-type mice (MBM-WT) and one Kv2.1 knockout (MBM-Kv2.1-KO) mouse. Samples courtesy of Dr. Jeanne Nerbonne, Washington University School of Medicine.

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)].

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

Price:

$345

Quantity:

Product Details

Target

Kv2.1 K+ channel

Target Description

Kv 2.1 K+ channel (Potassium voltage-gated channel subfamily B member 1), which is encoded by KCNB1 gene, is a member of the Potassium voltage-gated channel familly. This protein, mainly expressed in the central nervous system, functions as a delayed rectifier. Indeed, it regulates the action potential (AP) repolarization as well as duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells. Kv2.1 K+ channel switches between open or closed conformation in response to the voltage difference across the membrane. This process directs the voltage-dependent potassium ion permeability of excitable membranes, which lets potassium ions pass in accordance with their electrochemical gradient. Kv2.1 K+ channel is widely used as a marker to measure membrane excitability in hippocampal neurons.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K89/34

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Antigen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (also known as Potassium voltage-gated channel subfamily B member 1, Delayed rectifier potassium channel 1, DRK1, Kcnb1 and Shab, accession number P15387); Mouse: 100% identity (17/17 amino acids identical); Human: 88% identity (15/17 amino acids identical, RVLPGGGAHGSTRDQSI)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10673392

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against rat Kv2.2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

UniProt Details

UniProt (Human): Q14721
UniProt (Immunogen Species): P15387

Recover password

Create my account

Anti-Kv2.1 K+ Channel Antibody (K89/34)

Anti-Kv2.1 K+ Channel Antibody
SKU: 75-014

Product Details

Related Products

Recently Viewed

Anti-Kv2.1 K+ Channel Antibody (K89/34)

Anti-Kv2.1 K+ Channel Antibody SKU: 75-014

Product Details

Anti-Kv2.1 K+ Channel Antibody
SKU: 75-014