Name: Anti-GRIP1 Associated Protein 1 (GRASP1) Antibody
Brand: PhosphoSolutions
SKU: 642-GRASP
Price: 415.0 USD
Availability: InStock

Our Anti-GRIP1 Associated Protein 1 (GRASP1) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat GRIP1 Associated Protein 1 (GRASP1) and is antigen affinity purified from pooled serum. It is great for use in WB.

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Expected Reactivity

Bovine, Canine, Human

Applications

WB

Host Species

Rabbit

Format

Antigen Affinity Purified from Pooled Serum

Gene Name

GRIPAP1

Molecular Weight

95 kDa

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Western blot of rat cerebellar lysate showing the specific immunolabeling of the ~95 kDa GRASP protein.

Volume: 100 µL

Variant

Price:

$415

Quantity:

Bulk Order Anti-GRIP1 Associated Protein 1 (GRASP1) Antibody

Product Details

Target

GRIP1 Associated Protein 1 (GRASP1)

Target Description

PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000).

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

WB

Host Species

Rabbit

Gene Name

GRIPAP1

Molecular Weight

95 kDa

Antigen

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GRASP1, conjugated to keyhole limpet hemocyanin (KLH).

Species Reactivity

Mouse, Rat

Expected Reactivity

Bovine, Canine, Human

Antibody Registry ID

AB_2492135

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by affinity purification via chromatography on an affinity column made with the C-terminal peptide used as antigen.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~95 kDa GRASP1 protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

DKFZp434P0630 antibody, DXImx47e antibody, GRAP1_HUMAN antibody, GRASP 1 antibody, GRASP-1 antibody, GRASP1 antibody, GRIP 1 associated protein 1 antibody, GRIP associated protein 1 antibody, GRIP1 associated protein 1 antibody, GRIP1-associated protein 1 antibody, GRIPAP 1 antibody, GRIPAP1 antibody, KIAA1167 antibody, MGC126593 antibody, MGC126595 antibody, MPMGp800B12492Q3 antibody, Sfc10 antibody, TAMALIN antibody

UniProt Details

UniProt (Human): Q4V328
UniProt (Immunogen Species): Q9JHZ4

NCBI Gene ID

116493

Product Specific Protocols

Western Blot Protocol: Download

General References

Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1:133-141. PMID: 11252776
Ye B, Liao DZ, Zhang XQ, Zhang PS, Dong HL, Huganir RL (2000) GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26:603-617. PMID: 10896157

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Anti-GRIP1 Associated Protein 1 (GRASP1) Antibody

Our Anti-GRIP1 Associated Protein 1 (GRASP1) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat GRIP1 Associated Protein 1 (GRASP1) and is antigen affinity purified from pooled serum. It is great for use in WB.