Anti-Grb2 Antibody (M331)

Name: Anti-Grb2 Antibody
Brand: PhosphoSolutions
SKU: GM3311
Price: 340.0 USD
Availability: InStock

from PhosphoSolutions

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

M331

Applications

ICC, IP, WB

Host Species

Mouse

Format

Protein A Purified

Gene Name

GRB2

Molecular Weight

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Immunocytochemical labeling of Grb2 in rat PC12 cells differentiated with NGF. The cells were labeled with mouse monoclonal Grb2 (GM3311) antibody, then detected using appropriate secondary antibody conjugated to Cy3.

Volume: 100 µL

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$340

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Target

Grb2

Target Description

Crk and Grb2 family adaptor proteins are involved in a variety of cell signaling pathways related to human diseases. These adaptors have Src homology 2 (SH2) and Src homology 3 (SH3) domains, which are docking sites for several signaling proteins, including receptors, kinases, and GTPase regulators. In addItion, other protein-protein interactions may also utilize Crk and Grb2 domain interactions to modulate cell signaling pathways. The DOCK family of proteins (DOCK3, DOCK4, and DOCK5) can interact with Crk and may be important Crk effector proteins. The cell cycle regulator p27Kip1 can interact with Grb2, and this implicates Grb2 activity in cell signaling pathways that alter cell cycle progression.

Format

Protein A Purified

Clonality

Monoclonal

Clone

M331

Isotype

IgG1

Applications

ICC, IP, WB

Host Species

Mouse

Gene Name

GRB2

Molecular Weight

Antigen

Clone (M331) was generated from a full length recombinant rat Grb2 protein. This sequence has high homology to human and mouse Grb2.

Species Reactivity

Human, Mouse, Rat

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Dilution Ranges

WB: 1:1000
ICC: 1:50
IP: 1:50

Conjugate

Unconjugated

Specificity

This antibody detects a 24 kDa* protein corresponding to the molecular mass of Grb2 on SDS-PAGE immunoblots of rat PC12.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Grb

UniProt Details

UniProt (Human): P62993
UniProt (Immunogen Species): P62994

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Anti-Grb2 Antibody (M331)

Anti-Grb2 Antibody
SKU: GM3311

Bulk Order Anti-Grb2 Antibody

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