Anti-GluN2B/NR2B Glutamate Receptor Antibody (N59/36)

Our Anti-GluN2B/NR2B glutamate receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N59/36. It is KO validated, detects human, mouse, and rat GluN2B/NR2B glutamate receptor, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.



SKU: 75-101

Volume: 100 µL
Price:
Sale price$374

Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
377399651:100Maniv, I, et al. 2023. Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture model. Nature Communications, 5922.
Immunocytochemistry: Mouse
PMID Dilution Publication
349629571:200Lee, G.S., et al. 2021. 14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons. PloS One, e0261791.
Immunocytochemistry: Rat
PMID Dilution Publication
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342840421:1000Nuwer, J.L., et al. 2021. Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission. Neuropharmacology, 108724.
Immunohistochemistry: Mouse
PMID Dilution Publication
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Immunohistochemistry: Rat
PMID Dilution Publication
32726631not listedHolderith, N., et al. 2020. A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses. Cell Reports, 107968.
Western Blot: Human
PMID Dilution Publication
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Western Blot: Mouse
PMID Dilution Publication
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302886941:100Schroeder, E., et al. 2019. Neuron-type specific loss of CDKL5 leads to alterations in mTOR signaling and synaptic markers. Molecular Neurobiology, 4151-4162.
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Western Blot: Rat
PMID Dilution Publication
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331851901:200Sanders, S.S., et al. 2020. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. eLife, e56058.
330370731:1000Cochrane, V.A., et al. 2020. Leptin modulates pancreatic β-cell membrane potential through Src kinase–mediated phosphorylation of NMDA receptors. Journal of Biological Chemistry, 17281–17297.
323490751:2000Zang, K.K., et al. 2020. Distinct Function of Estrogen Receptors in the Rodent Anterior Cingulate Cortex in Pain-related Aversion. Anesthesiology, 165-184.
319966791:500Washburn, H.R., et al. 2020. Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility. Nature Communications, 570.
318010621:1000Paskus, J.D., et al. 2019. Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action. Cell Reports, 2944-2952.e5.
309273621:500Durante, V., et al. 2019. Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration. Brain, 1365-1385.
303969971:500Esmenjaud, J.B., et al. 2019. An inter-dimer allosteric switch controls NMDA receptor activity. The EMBO Journal, e99894.
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Additional Publications: Unspecified
PMID Publication
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27713495Tian, M., et al. 2016. Allosteric regulation in NMDA receptors revealed by the genetically encoded photo-cross-linkers. Scientific Reports, 34751.
27595347Clairfeuille, T., et al. 2016. A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex.. Nature Structural & Molecular Biology, 921-932.
27492494Jaramillo, T.C., et al. 2016. Novel Shank3 Mutant Exhibits Behaviors With Face Validity for Autism and Altered Striatal and Hippocampal Function. Autism Research, 42-65.
27480238Lie, E., et al. 2016. SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.. Nature Communications, 12328.
27457929Won, S., et al. 2016. PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61.. Proceedings of the National Academy of Science of the United States of America, E4736-44.
27335408Xiao, X., et al. 2016. Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice. The Journal of Neuroscience, 6778–6791.
27216994Kaniakova, M., et al. 2016. Biochemical and electrophysiological characterization of N-glycans on NMDA receptor subunits. Journal of Neurochemistry, 546-556.
27161151Wang, X., et al. 2016. Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.. Nature Communications, 11459.
26930443Rambousek, L., et al. 2016. Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits. Neuropharmacology, 594-606.
26714288Moraga-Amaro, R., et al. 2016. Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory.. Neuropharmacology, 222-235.
26679993Stanic, J., et al. 2015. Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.. Nature Communications, 10181.
26665164Tao-Cheng, J.H., et al. 2015. Depolarization of hippocampal neurons induces formation of nonsynaptic NMDA receptor islands resembling nascent postsynaptic densities. Eneuro, ENEURO.0066-15.
26590557Tapia-Rojas, C., et al. 2015. Is L-methionine a trigger factor for Alzheimer''s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice.. Molecular Neurodegeneration, 62.
26553645Park, H., et al. 2015. Mice lacking the PSD-95–interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation and impaired contextual …. Scientific reports, 16410.
26481044Stein, L.R., et al. 2015. Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors.. Brain Research Bulletin, 41-51.
26479588Hruska, M., et al. 2015. Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3.. Nature Neuroscience, 1594-1605.
26321637Li, Y., et al. 2015. Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion.. Cell Report, 1618-1630.
26241953Hanno-Iijima, Y., et al. 2015. Activity-Dependent Bidirectional Regulation of GAD Expression in a Homeostatic Fashion Is Mediated by BDNF-Dependent and Independent Pathways. PLoS One, e0134296.
25822337Balsara, R., et al. 2015. Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke.. PLoS One, e0122840.
25771393Cristino, L., et al. 2015. d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain.. Neurobiology of Aging, 1890-1902.
25653350Zhang, N., et al. 2015. S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model.. Journal of Neuroscience, 1892-1904.
25644714DiBattista, A.M., et al. 2015. Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.. Biochimica et Biophysica Acta, 904-917.
25524173Serrano, F.G., et al. 2014. Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice.. Molecular Neurodegeneration, 61.
25510858Mulholland, P.J., et al. 2014. Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus.. Psychopharmacology, 1995-2006.
25505316Stroebel, D., et al. 2014. Controlling NMDA receptor subunit composition using ectopic retention signals.. Journal of Neuroscience, 16630-16636.
25471585Warmus, B.A., et al. 2014. Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.. Journal of Neuroscience, 16482-16495.
25232120Fitting, S., et al. 2014. Interactive HIV-1 Tat and morphine-induced synaptodendritic injury is triggered through focal disruptions in Na⁺ influx, mitochondrial instability, and Ca²⁺ overload.. Journal of Neuroscience, 12850-12864.
24941251Dai, S.H., et al. 2014. Activation of mGluR5 Attenuates NMDA-Induced Neurotoxicity through Disruption of the NMDAR-PSD-95 Complex and Preservation of Mitochondrial Function in Differentiated PC12 Cells. International Journal of Molecular Sciences, 10892-10907.
24874075Plowey, E.D., et al. 2014. Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration.. Biochimica et Biophysica Acta, 1596-1603.
24501359Vargas, J.Y., et al. 2014. In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer''s disease model.. Journal of Neuroscience, 2191-2202.
24498267Landgraf, P., et al. 2014. Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK.. PLoS One, e85924.
24486947Tronci, E., et al. 2014. Effect of memantine on L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson''s disease.. Neuroscience, 245-252.
24440698Muñoz, F.J., et al. 2014. Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons.. Biochemical and Biophysical Research Communications, 189-194.
24360280Parkhurst, C.N., et al. 2013. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.. Cell, 1596-609.
24068818Krüger, J.M., et al. 2013. Differential roles of postsynaptic density-93 isoforms in regulating synaptic transmission.. Journal of Neuroscience, 15504-15517.
24012668Sohn, Y.I., et al. 2013. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.. Biochemical and Biophysical Research Communications, 464-470.
23946397Bonnet, S.A., et al. 2013. Synaptic state-dependent functional interplay between postsynaptic density-95 and synapse-associated protein 102.. Journal of Neuroscience, 13398-13409.
23926248Prox, J., et al. 2013. Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.. Journal of Neuroscience, 12915-12928.
23884936Zamzow, D.R., et al. 2013. An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging.. Journal of Neuroscience, 12300-12305.
23805233Csölle, C., et al. 2013. Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors.. PLoS One, e66547.
23540692Li, L., et al. 2013. Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion.. Cell, 86-100.
23486974Murata, Y., et al. 2013. Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.. Journal of Neuroscience, 5040-5052.
23103165Chen, B.S., et al. 2012. SAP102 mediates synaptic clearance of NMDA receptors.. Cell Report, 1120-1128.
22902837She, K., et al. 2012. Differential stimulus-dependent synaptic recruitment of CaMKIIα by intracellular determinants of GluN2B.. Molecular and Cellular Neuroscience, 68-78.
22869717Ardiles, A.O., et al. 2012. Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer''s disease.. Proceedings of the National Academy of Science of the United States of America, 13835–13840.
22740692She, K., et al. 2012. Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.. The Journal of Biological Chemistry, 27432–27445.
22593065Danielson, E., et al. 2012. S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors.. Journal of Neuroscience, 6967–6980.
22832522Inestrosa, N.C., et al. 2011. Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer''s disease: a possible effect on APP processing.. Translational Psychiatry, e20.
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21795692Verpelli, C., et al. 2011. Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.. The Journal of Biological Chemistry, 34839–34850.
21762461Badanich, K.A., et al. 2011. NR2B-Deficient Mice are More Sensitive to the Locomotor Stimulant and Depressant Effects of Ethanol. Genes, Brain and Behavior, 805-816.
21496646Zhang, J., et al. 2011. The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior.. Cell, 284-299.
21092855Micheva, K.D., et al. 2010. Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers.. Neuron, 639-653.
20678574Antion, M.D., et al. 2010. Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses.. Molecular and Cellular Neuroscience, 378-388.
19158293Gardoni, F., et al. 2009. Decreased NR2B subunit synaptic levels cause impaired long-term potentiation but not long-term depression.. The Journal of Neuroscience, 669-677.

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