Glutamate receptor NMDA2A or GluN2A/NR2A glutamate receptor is a member of the glutamate-gated ion channel family. NR2A is a subunit of the ligand-gated ion channel with high calcium permeability and voltage-dependent sensitivity to magnesium. NR2A is expressed throughout the brain, including striatum, forbrain, cerebellum (at protein level) brain cortex, piriform cortex, hippocampus, caudate-putamen, dentate gyrus and granule cell layer. It is found at the postsynaptic cell membrane, dendritic spine, synapse, and cytoplasmic vesicle membrane. A variety of neurological diseases, including epilepsy, intellectual disability, autism spectrum disorders, developmental delay, and schizophrenia are associated with mutations in the NR2A gene.
Purified
1 mg/mL
Monoclonal
N327/95
IgG2a
IHC, WB
Mouse
Grin2a
170 kDa
Fusion protein amino acids 75-325 (extracellular N-terminus) of rat NR2A (also known as Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D aspartate receptor subtype 2A, Grin2a, NMDAR2A, accession number Q00959); Mouse: 99% identity (250/251 amino acids identical); Human: 97% identity (245/252 amino acids identical); Greater than 60% identity with NR2B
Human, Mouse, Rat
AB_2315842
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Unconjugated
Does not cross-react with GluN2B/NR2B
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
