Name: Anti-GluA1/GluR1 Glutamate Receptor Antibody
Brand: NeuroMab
SKU: 75-327
Price: 335.0 USD
Availability: InStock

Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Gria1 Glur1

Molecular Weight

100 kDa

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Immunofluorescence staining of 14 DIV cultured rat cortical neuron with N355/1. Image courtesy of Brad Elmer and Kim McAllister (UCD).

Adult rat hippocampus immunohistochemistry.

Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged GluR1, GluR2 or Kv2.1 plasmid and probed with N355/1 (left), L21/32 (middle) or N52A/42 (right) TC supe.

Immunofluorescence staining of 14 DIV cultured rat cortical neuron with N355/1. Image courtesy of Brad Elmer and Kim McAllister (UCD).

Volume: 100 µL

Variant

Price:

$335.00

Quantity:

Product Details

Target

Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1)

Target Description

Glutamate receptor 1 or GluA1/GluR1 glutamate receptor is a member of the glutamate-gated ion channel family. GluR1 funcitons as an excitatory neurotransmitter at many synapses in the central nervous system and is widely expressed in brain. Mutations in the GluR1 gene are associated with cerebral cortical dysplasia, Status Epilepticus, and depression.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N355/1

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Gria1 Glur1

Molecular Weight

100 kDa

Antigen

Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1 (also known as Glutamate receptor 1, Ionotropic AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, GLUH1 and Gria1, accession number P19490) Mouse: 99% identity (388/389 amino acids identical); Human: 97% identity (379/389 amino acids identical); 100% identity between Flip and Flop isoforms; Greater than 50% identity with GluA2/GluR2, GluA3/GluR3 and GluA4/GluR4

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315840

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

Does not cross-react with GluR2

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1)

UniProt Details

UniProt (Human): P42261
UniProt (Immunogen Species): P19490

Citations (11)

Loh KH, Stawski PS, Draycott AS, Udeshi ND, Lehrman EK, Wilton DK, Svinkina T, Deerinck TJ, Ellisman MH, Stevens B, Carr SA, Ting AY. (2016), 'Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts..' Cell. 10.1016/j.cell.2016.07.041.
Vingtdeux V, Chang EH, Frattini SA, Zhao H, Chandakkar P, Adrien L, Strohl JJ, Gibson EL, Ohmoto M, Matsumoto I, Huerta PT, Marambaud P. (2016), 'CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice..' Sci Rep. 10.1038/srep24250.
Moraga-Amaro R, González H, Ugalde V, Donoso-Ramos JP, Quintana-Donoso D, Lara M, Morales B, Rojas P, Pacheco R, Stehberg J. (2016), 'Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory..' Neuropharmacology. 10.1016/j.neuropharm.2015.12.018.
Bellizzi MJ, Geathers JS, Allan KC, Gelbard HA. (2016), 'Platelet-Activating Factor Receptors Mediate Excitatory Postsynaptic Hippocampal Injury in Experimental Autoimmune Encephalomyelitis..' J Neurosci. 10.1523/JNEUROSCI.1171-15.2016.
Lv JM, Guo XM, Chen B, Lei Q, Pan YJ, Yang Q. (2016), 'The Noncompetitive AMPAR Antagonist Perampanel Abrogates Brain Endothelial Cell Permeability in Response to Ischemia: Involvement of Claudin-5..' Cell Mol Neurobiol. 10.1007/s10571-015-0257-8.
Tempia F, Hoxha E, Negro G, Alshammari MA, Alshammari TK, Panova-Elektronova N, Laezza F. (2015), 'Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27..' Front Cell Neurosci. 10.3389/fncel.2015.00205.
Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett-Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P. (2015), 'Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons..' Proc Natl Acad Sci U S A. 10.1073/pnas.1423205112.
Cristino L, Luongo L, Squillace M, Paolone G, Mango D, Piccinin S, Zianni E, Imperatore R, Iannotta M, Longo F, Errico F, Vescovi AL, Morari M, Maione S, Gardoni F, Nisticò R, Usiello A. (2015), 'd-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain..' Neurobiol Aging. 10.1016/j.neurobiolaging.2015.02.003.
de Andrade GB, Kunzelman L, Merrill MM, Fuerst PG. (2014), 'Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina..' Mol Vis. .
Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR rd, Lafaille JJ, Hempstead BL, Littman DR, Gan WB. (2013), 'Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor..' Cell. 10.1016/j.cell.2013.11.030.
Luo P, Yang Y, Liu W, Rao W, Bian H, Li X, Chen T, Liu M, Zhao Y, Dai S, Yan X, Fei Z. (2013), 'Downregulation of postsynaptic density-95-interacting regulator of spine morphogenesis reduces glutamate-induced excitotoxicity by differentially regulating glutamate receptors in rat cortical neurons..' FEBS J. 10.1111/febs.12531.

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Anti-GluA1/GluR1 Glutamate Receptor Antibody (N355/1)

Anti-GluA1/GluR1 Glutamate Receptor Antibody
SKU: 75-327

Product Details

Citations (11)

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Anti-GluA1/GluR1 Glutamate Receptor Antibody (N355/1)

Anti-GluA1/GluR1 Glutamate Receptor Antibody SKU: 75-327

Product Details

Citations (11)

Anti-GluA1/GluR1 Glutamate Receptor Antibody
SKU: 75-327