Name: Anti-GABAB Receptor (Ser923), R1-Subunit Antibody
Brand: PhosphoSolutions
SKU: p1148-923
Price: 415.0 USD
Availability: InStock

Our Anti-GABAB Receptor (Ser923), R1-Subunit rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat GABAB Receptor (Ser923), R1-Subunit and is antigen affinity purified from pooled serum. It is great for use in WB.

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Expected Reactivity

Bovine, Human, Non-Human Primate

Applications

WB

Host Species

Rabbit

Format

Antigen Affinity Purified from Pooled Serum

Gene Name

GABBR1

Molecular Weight

102 kDa

Go to Full Product Details

Western blot of rat synaptic membrane lysate showing specific immunolabeling of the ~102 kDa GABAB R1 protein phosphorylated at Ser923 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (λ-Ptase, 1200 units for 30 min).

Volume: 100 µL

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Price:

$415

Quantity:

Bulk Order Anti-GABAB Receptor (Ser923), R1-Subunit Antibody

Product Details

Target

GABAB Receptor (Ser923), R1-Subunit

Target Description

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-B receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABA-B receptor effector coupling (Couve et al., 2004). Phosphorylation of Ser-923 is thought to be important in the regulation of GABA-B receptor function.

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

WB

Host Species

Rabbit

Gene Name

GABBR1

Molecular Weight

102 kDa

Antigen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 of the R1-subunit of rat GABAB receptor, conjugated to keyhole limpet hemocyanin (KLH).

Species Reactivity

Mouse, Rat

Expected Reactivity

Bovine, Human, Non-Human Primate

Antibody Registry ID

AB_2492118

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~102 kDa GABAB R1 phosphorylated at Ser923. Immunolabeling is completely eliminated by treatment with λ-phosphatase.

Post Translational Modification Type

Phosphorylated

Post Translational Modification Residue

Ser923

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

dJ271M21.1.1 antibody, dJ271M21.1.2 antibody, FLJ92613 antibody, GABA-B receptor 1 antibody, GABA-B-R1 antibody, GABA-BR1 antibody, GABAB R1 antibody, GABAB subunit 1c antibody, GABABR1 antibody, GABBR1 3 antibody, GABBR1 antibody, GABR1_HUMAN antibody, Gamma aminobutyric acid (GABA) B receptor 1 antibody, Gamma-aminobutyric acid type B receptor subunit 1 antibody, Gb1 antibody, GPRC3A antibody, Seven transmembrane helix receptor antibody

UniProt Details

UniProt (Human): Q9UBS5
UniProt (Immunogen Species): Q9Z0U4

NCBI Gene ID

81657

Product Specific Protocols

Western Blot Protocol: Download

General References

Couve A, Calver AR, Fairfax B, Moss SJ, Pangalos MN (2004) Unraveling the unusual signaling properties of the GABA(B) receptor. Biochem. Pharmacol. Oct 15;68(8):1527-36. PMID: 15451395

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Anti-GABAB Receptor (Ser923), R1-Subunit Antibody

Our Anti-GABAB Receptor (Ser923), R1-Subunit rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat GABAB Receptor (Ser923), R1-Subunit and is antigen affinity purified from pooled serum. It is great for use in WB.