Name: Anti-GABAA Receptor γ2 Antibody
Brand: PhosphoSolutions
SKU: 830-GG2
Price: 360.0 USD
Availability: InStock

Our Anti-GABAA Receptor γ2 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat GABAA Receptor γ2 and is neat pooled serum. It is great for use in WB, IHC.

Product Type

Primary Antibody

Species Reactivity

Rat

Expected Reactivity

Chicken, Human, Non-Human Primate, Zebrafish

Applications

IHC, WB

Host Species

Rabbit

Format

Neat Pooled Serum

Gene Name

GABRG2

Molecular Weight

46 kDa

Go to Full Product Details

Immunostaining of rat cerebellum showing labeling of GABAA γ2 subunit in fuchsia.

Western blot of 10 µg of rat hippocampal lysate showing specific immunolabeling of the ~46 kDa γ2-subunit of the GABAA-R.

Volume: 50 µL

Variant

Price:

$360

Quantity:

Bulk Order Anti-GABAA Receptor γ2 Antibody

Product Details

Target

GABAA Receptor γ2

Target Description

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, co-expression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). Lastly, phosphorylation of β-subunits of the receptor has been shown to modulate GABA-A-R function (Brandon et al., 2003).

Format

Neat Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Rabbit

Gene Name

GABRG2

Molecular Weight

46 kDa

Antigen

Synthetic peptide corresponding to amino acid residues specific to the γ2 subunit of rat GABAA receptor, conjugated to keyhole limpet hemocyanin (KLH).

Species Reactivity

Rat

Expected Reactivity

Chicken, Human, Non-Human Primate, Zebrafish

Antibody Registry ID

AB_2492114

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Pooled neat serum

Buffer

neat serum

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000
IHC: 1:400

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~46 kDa γ2-subunit of the GABAA receptor.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

CAE 2 antibody, CAE2 antibody, ECA 2 antibody, ECA2 antibody, GABA(A) receptor gamma 2 antibody, GABA(A) receptor subunit gamma 2 antibody, GABA(A) receptor subunit gamma-2 antibody, GABRG 2 antibody, GABRγ2 antibody, Gamma aminobutyric acid (GABA) A receptor gamma 2 antibody, Gamma aminobutyric acid A receptor gamma 2 antibody, Gamma aminobutyric acid receptor gamma 2 subunit antibody, Gamma-aminobutyric acid receptor subunit gamma-2 antibody, GBRG2_HUMAN antibody, GEFSP 3 antibody, GEFSP3 antibody

UniProt Details

UniProt (Human): P18507
UniProt (Immunogen Species): P18508

NCBI Gene ID

29709

Product Specific References for Applications and Species

Western Blot: Mouse

Western Blot: Mouse
PMID	Dilution	Publication
32719118	1:2000	Fagan, M.P., et al. 2020. . Essential and sex-specific effects of mGluR5 in ventromedial hypothalamus regulating estrogen signaling and glucose balance. Proceedings of the National Academy of Sciences.

Product Specific Protocols

Western Blot Protocol: Download

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Anti-GABAA Receptor γ2 Antibody

Our Anti-GABAA Receptor γ2 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat GABAA Receptor γ2 and is neat pooled serum. It is great for use in WB, IHC.