Anti-Caspase-3 (p17 subunit) Antibody (31A1067)

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Our Caspase-3 (p17 subunit) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Caspase-3 (p17 subunit) and is Protein G purified. It is great for use in WB, IHC.

Western blot analysis of Caspase-3 in multiple human tissues using CM4911 at 1:100. The tissues shown are A) brain, B) heart, C) intestine, D) kidney, E) liver, F) lung, G) muscle, H) stomach, I) spleen, J) ovary, and K) testis. Lanes 1, 2 and 3 demonstrate the species crossreactivity of the antibody in human, mouse and rat heart lysate, respectively.
Induction of apoptosis after combination treatment was marked by poly (ADP-ribose) polymerase (PARP) cleavage and caspase-3 (cat. CM4911) activation. Western blots of single or combination treatment of LNCaP (48 h), DU145, PC-3 or CHO cells (all 72 h) with 1.0 µg/ml SO1861 and 2.5 nM EGF-PE24mutΔREDLK. β-actin was used as a loading control. *CHO cells are not of human origin - detection of human Caspase-3 was not possible in this cell line. Image from publication CC-BY-4.0. PMID: 37859824
Western blot analysis of Caspase-3 in multiple human tissues using CM4911 at 1:100. The tissues shown are A) brain, B) heart, C) intestine, D) kidney, E) liver, F) lung, G) muscle, H) stomach, I) spleen, J) ovary, and K) testis. Lanes 1, 2 and 3 demonstrate the species crossreactivity of the antibody in human, mouse and rat heart lysate, respectively.
Western blot analysis of Caspase-3 in multiple human tissues using CM4911 at 1:100. The tissues shown are A) brain, B) heart, C) intestine, D) kidney, E) liver, F) lung, G) muscle, H) stomach, I) spleen, J) ovary, and K) testis. Lanes 1, 2 and 3 demonstrate the species crossreactivity of the antibody in human, mouse and rat heart lysate, respectively.
Induction of apoptosis after combination treatment was marked by poly (ADP-ribose) polymerase (PARP) cleavage and caspase-3 (cat. CM4911) activation. Western blots of single or combination treatment of LNCaP (48 h), DU145, PC-3 or CHO cells (all 72 h) with 1.0 µg/ml SO1861 and 2.5 nM EGF-PE24mutΔREDLK. β-actin was used as a loading control. *CHO cells are not of human origin - detection of human Caspase-3 was not possible in this cell line. Image from publication CC-BY-4.0. PMID: 37859824
Human, Mouse, Rat
IHC, WB
Mouse

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from PhosphoSolutions

SKU: CM4911

Volume: 100 µL
Price:
$275

Product Specific References for Applications and Species

Western Blot: Human
PMID Dilution Publication
33260619not listedFischer, A, et al. 2020. Pseudomonas Exotoxin A Based Toxins Targeting Epidermal Growth Factor Receptor for the Treatment of Prostate Cancer. Toxins, 753.
Western Blot: Mouse
PMID Dilution Publication
32580291not listedMasilamani, AP, et al. 2020. An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells. Cancers, 1648.
Western Blot: Plant
PMID Dilution Publication
37859824not listedFischer, A, et al. 2023. Synergistic Cytotoxicity of a Toxin Targeting the Epidermal Growth Factor Receptor and the Glycosylated Triterpenoid SO1861 in Prostate Cancer. Journal of Cancer, 3039-3049.

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