New Tyrosine Hydroxylase LNC1 Mouse Monoclonal Antibody

Check out new mouse monoclonal tyrosine hydroxylase, non-ascities antibody from the LNC1 clone developed by Dr. Gregory Kapatos!

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine.  TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001, Zhu et al., 2000, Zhu et al.,1999).  TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001, Dunkley et al., 2004). LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH.

LNC1 Tyrosine Hydroxylase Product Spotlight

 

PRODUCTFORMSIZECAT. NO.PRICE
Tyrosine Hydroxylase (LNC1) AntibodyMouse monoclonal, Affinity Purified25 or 100 uL2026-LNC1$119 – $380

General References

  1. Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW (2004) Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem 91:1025-1043.
  2. Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.
  3. Witkovsky P, Gabriel R, Haycock JW, Meller E (2000) Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina. J Chem Neuroanat 19:105-116.
  4. Zhu MY, Klimek V, Haycock JWOrdway GA (2000) Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain. J Neurosci Meth 99:37-44.
  5. Zhu MY, Klimek V, Dilley GE, Haycock JW, Stockmeier C, Overholser JC, Meltzer HY, Ordway GA (1999) Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry 46:1275-1286.