FOR NEUROSCIENCE RESEARCH: Anti-Rabbit and Anti-Guinea Pig

RBPMS (RNA binding protein with multiple splicing), also known as HERMES, contains one RRM (RNA recognition motif) domain and belongs to the RRM family of RNA-binding proteins. RBPMS exists as multiple alternatively spliced isoforms and is thought to bind RNA, possibly playing a role in RNA-related events, such as transcription and translation. RNA-binding proteins that are specific to retinal ganglion cells (RGCs) have been previously identified as excellent markers for RGCs (Kwong et al., 2010). Recent findings show that antibodies against RBPMS are robust reagents that exclusively identify RGCs in multiple mammalian species (Rodriguez et al. 2014).

PhosphoSolutions offers high-quality RBPMS antibodies from two different species making it easy to check for cross-reactivity.

RBPMS, rabbit
Rabbit Polyclonal, Affinity Purified100 ul1830-RBPMS$345.002,5,6,8,9,11
RBPMS, guinea pig Guinea Pig Polyclonal, Affinity Purified100 ul1832-RBPMS$345.001,3,4,7,10

Product Specific References

  1. Ueki, Y., Ramirez, G., Salcedo, E., Stabio, M.E. and Lefcort, F., 2016. Loss of Ikbkap causes slow, progressive retinal degeneration in a mouse model of Familial Dysautonomia. eneuro, 3(5), pp.ENEURO-0143. PMID: 27699209
  2. Chen, L. and Gage, P.J., 2016. Heterozygous Pitx2 Null Mice Accurately Recapitulate the Ocular Features of Axenfeld-Rieger Syndrome and Congenital Glaucoma. Investigative Ophthalmology & Visual Science, 57(11), pp.5023-5030. PMID: 27654429
  3. Obara, E. A., Hannibal, J., Heegaard, S., & Fahrenkrug, J. (2016). Loss of Melanopsin-Expressing Retinal Ganglion Cells in Severely Staged Glaucoma PatientsMelanopsin Expression in Glaucoma Patients. Investigative Ophthalmology & Visual Science, 57(11), 4661-4667. PMID: 27583827
  4. Long, Y., Bordt, A. S., Liu, W. S., Davis, E. P., Lee, S. J., Tseng, L., Chuang, A.Z., Whitaker, C.M., Massey, S.C., Sherman, M.B., & Marshak, D. W. (2016). Wide-field diffuse amacrine cells in the monkey retina contain immunoreactive Cocaine-and Amphetamine-Regulated Transcript (CART). Peptides, 84, 22-35. PMID: 27568514
  5. Lim, J. H. A., Stafford, B. K., Nguyen, P. L., Lien, B. V., Wang, C., Zukor, K., He, Z. & Huberman, A. D. (2016). Neural activity promotes long-distance, target-specific regeneration of adult retinal axons. Nature Neuroscience. PMID: 27399843
  6. Vargas, J. L. C., Belforte, N., & Di Polo, A. (2016). The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling. Neurobiology of disease, 93, 156-171. PMID: 27163643
  7. Boggio, E. M., Pancrazi, L., Gennaro, M., Rizzo, C. L., Mari, F., Meloni, I., Ariani, F., Panighini, A., Novelli, E., Biagioni, M., Strettoi, E., Hayek, J., Rufa, A., Pizzorusso, T., Renieri, A., & Strettoi, E. (2016). Visual impairment in FOXG1-mutated individuals and mice. Neuroscience, 324, 496-508. PMID: 27001178
  8. Shabanzadeh, A. P., D’onofrio, P. M., Monnier, P. P., & Koeberle, P. D. (2015). Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke. Cell death & disease, 6(11), e1967. PMID: 26539914
  9. Vargas, J. L. C., Osswald, I. K., Unsain, N., Aurousseau, M. R., Barker, P. A., Bowie, D., & Di Polo, A. (2015). Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation. The Journal of Neuroscience, 35(35), 12088-12102. PMID: 26338321
  10. Pérez de Sevilla Müller, L., Sargoy, A., Fernández‐Sánchez, L., Rodriguez, A., Liu, J., Cuenca, N., & Brecha, N. (2015). Expression and cellular localization of the voltage‐gated calcium channel α2δ3 in the rodent retina. Journal of Comparative Neurology, 523(10), 1443-1460. PMID: 25631988
  11. Reifler, A. N., Chervenak, A. P., Dolikian, M. E., Benenati, B. A., Meyers, B. S., Demertzis, Z. D., Lynch, A.M., Li, B.Y., Wachter, R.D., Abufarha, F.S., Dulka, E.A., Pack, W., Zhao, X., & Wong, K. Y. (2015). The rat retina has five types of ganglion-cell photoreceptors. Experimental eye research, 130, 17-28. PMID: 25450063

General References

  1. Rodriguez AR, de Sevilla Müller LP, Brecha NC (2014) The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina. J Comp Neurol. Apr 15;522(6):1411-43.
  2. Kwong JM, Caprioli J, Piri N (2010) RNA binding protein with multiple splicing: a new marker for retinal ganglion cells. Invest Ophthalmol Vis Sci. Feb;51(2):1052-8.